Anxiety Curing Evaluation with the Aqueous Extract of <i>Securidaca longepedunculata </i>(<i>Polygalaceae</i>) <i>Decoction</i> in Mice on the Stress Paradigm Tests

Securidaca longepedunculata is a plant which various parts are widely used in traditional medicine. Its roots to treat snakebite. Beyond its efficacy for snakebite treatment, S. longepedunculata the treatment of other diseases including dysentery, stomach ache and mental disorders. The interest present study was investigate anxiolytic properties S. decoction. material our consisted roots. animal male female Mus musculus Swiss mice 18 g above, approximately 9 weeks old not previously tested. They were acute toxicity assessment following OECD 425 protocols. Then evaluation activity decoction on chronic anxiety done using paradigms: Elevated Plus Maze (EPM), Open Field (OF), Hole Board (HB) Restrictor. Finally, some oxidative stress parameters such as catalase, sulfoxide dismutase, reduced glutathione malondialdehyde measured. screening revealed presence phenolic compounds like flavonoids, saponosides triterpenes. There no signs at dose 5000 mg/kg fourteen (14) days after treatment. this through different tests showed that, most effective 213 mg/kg. In EPM test, there significant (p<0.001) increase number entries into open arms from 7±1.30 negative control 36 ±3.16 (Sl mg/kg) group. Diazepam also induced number. time spent their respective percentages equally increased. However, decrease closed indicating level these mice. OF HB would possess properties. This could be justified by secondary metabolites saponins flavonoids. These results justify use medicine It beneficial suggest them local populations against pathologies.